載入...

RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors

PURPOSE: Malignant peripheral nerve sheath tumors (MPNSTs) are deadly sarcomas that lack effective therapies. In most MPNSTs, the retinoblastoma (RB1) tumor suppressor is disabled by hyperactivation of cyclin dependent kinases (CDKs), commonly through loss of CDK inhibitory proteins such as p27(Kip1...

全面介紹

Na minha lista:
書目詳細資料
發表在:Clin Cancer Res
Main Authors: Kohlmeyer, Jordan L, Kaemmer, Courtney A, Pulliam, Casey, Maharjan, Chandra K, Moreno Samayoa, Allison, Major, Heather, Cornick, Kendall, Knepper-Adrian, Vickie, Khanna, Rajesh, Sieren, Jessica C, Leidinger, Mariah R., Meyerholz, David K., Zamba, Gideon, Weimer, Jill M, Dodd, Rebecca D, Darbro, Benjamin W, Tanas, Munir R, Quelle, Dawn E
格式: Artigo
語言:Inglês
出版: 2020
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299809/
https://ncbi.nlm.nih.gov/pubmed/32086342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-2706
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!