RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors

PURPOSE: Malignant peripheral nerve sheath tumors (MPNSTs) are deadly sarcomas that lack effective therapies. In most MPNSTs, the retinoblastoma (RB1) tumor suppressor is disabled by hyperactivation of cyclin dependent kinases (CDKs), commonly through loss of CDK inhibitory proteins such as p27(Kip1...

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Publicado no:Clin Cancer Res
Main Authors: Kohlmeyer, Jordan L, Kaemmer, Courtney A, Pulliam, Casey, Maharjan, Chandra K, Moreno Samayoa, Allison, Major, Heather, Cornick, Kendall, Knepper-Adrian, Vickie, Khanna, Rajesh, Sieren, Jessica C, Leidinger, Mariah R., Meyerholz, David K., Zamba, Gideon, Weimer, Jill M, Dodd, Rebecca D, Darbro, Benjamin W, Tanas, Munir R, Quelle, Dawn E
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299809/
https://ncbi.nlm.nih.gov/pubmed/32086342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-2706
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