TAp63-regulated microRNAs suppress cutaneous squamous cell carcinoma through inhibition of a network of cell cycle genes

TAp63 is a p53 family member and potent tumor and metastasis suppressor. Here, we show that TAp63(−/−) mice exhibit an increased susceptibility to UVR-induced cutaneous squamous cell carcinoma (cuSCC). A human-to-mouse comparison of cuSCC tumors identified miR-30c-2* and miR-497 as underexpressed in...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Davis, Andrew J., Tsinkevich, Maksym, Rodencal, Jason, Abbas, Hussein A., Su, Xiao-hua, Gi, Young-Jin, Fang, Bin, Rajapakshe, Kimal, Coarfa, Cristian, Gunaratne, Preethi H., Koomen, John M., Tsai, Kenneth Y., Flores, Elsa R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299759/
https://ncbi.nlm.nih.gov/pubmed/32156775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1892
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