Investigating PSMA-targeted radioligand therapy efficacy as a function of cellular PSMA levels and intra-tumoral PSMA heterogeneity

PURPOSE: Prostate specific membrane antigen (PSMA) targeting radioligands deliver radiation to PSMA expressing cells. However, the relationship between PSMA levels and intra-lesion heterogeneity of PSMA expression, and cytotoxic radiation by radioligand therapy (RLT) is unknown. Here we investigate...

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Publicado no:Clin Cancer Res
Main Authors: Current, Kyle, Meyer, Catherine, Magyar, Clara, Mona, Christine E., Almajano, Joel, Slavik, Roger, Stuparu, Andreea D., Cheng, Chloe, Dawson, David W., Radu, Caius G., Czernin, Johannes, Lückerath, Katharina
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299755/
https://ncbi.nlm.nih.gov/pubmed/31932492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-1485
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