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Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans
In Caenorhabditis elegans, mutations in WDR-5 and other components of the COMPASS H3K4 methyltransferase complex extend lifespan and enable its inheritance. Here, we show that wdr-5 mutant longevity is itself a transgenerational trait that corresponds with a global enrichment of the heterochromatin...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7299346/ https://ncbi.nlm.nih.gov/pubmed/31815663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48498 |
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