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Novel ovarian cancer maintenance therapy targeted at mortalin and mutant p53

Current ovarian cancer maintenance therapy is limited by toxicity and no proven impact on overall survival. To study a maintenance strategy targeted at missense mutant p53, we hypothesized that the release of mutant p53 from mortalin inhibition by the SHetA2 drug combined with reactivation of mutant...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Ramraj, Satish K., Elayapillai, Sugantha P., Pelikan, Richard C., Zhao, Yan D., Isingizwe, Zitha R., Kennedy, Amy L., Lightfoot, Stanley A., Benbrook, Doris M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7297651/
https://ncbi.nlm.nih.gov/pubmed/31845320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.32830
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