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Severing Ties: Quantifying the Payload Release from Antibody Drug Conjugates
As a key mediator of efficacy and toxicity, the linker connecting the payload in antibody drug conjugates determines cellular distribution and payload release. Sorkin et al. (2016) have created novel fluorescence-based linkers to quantify the rate of intracellular bond cleavage and track live-cell k...
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| Publicado en: | Cell Chem Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7297053/ https://ncbi.nlm.nih.gov/pubmed/31951577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.12.001 |
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