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Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression

Accumulating evidence implicates dysregulation of hippocampal synaptic plasticity in the pathophysiology of depression. However, the effects of ketamine on synaptic plasticity and their contribution to its mechanism of action as an antidepressant, are still unclear. We investigated ketamine’s effect...

詳細記述

保存先:
書誌詳細
出版年:Mol Brain
主要な著者: Aleksandrova, Lily R., Wang, Yu Tian, Phillips, Anthony G.
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296711/
https://ncbi.nlm.nih.gov/pubmed/32546197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-020-00627-z
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