The Antidepressant-Like Effects of a Clinically Relevant Dose of Ketamine Are Accompanied by Biphasic Alterations in Working Memory in the Wistar Kyoto Rat Model of Depression

Major depressive disorder (MDD) is the leading cause of disability worldwide. The majority of antidepressant drugs require several weeks or months of treatment to demonstrate efficacy and a subset of patients are resistant to such interventions. Ketamine demonstrates rapid and long-lasting antidepre...

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Detalhes bibliográficos
Publicado no:Front Psychiatry
Main Authors: McDonnell, Conor W., Dunphy-Doherty, Fionn, Rouine, Jennifer, Bianchi, Massimiliano, Upton, Neil, Sokolowska, Ewa, Prenderville, Jack A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Psychiatry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863985/
https://ncbi.nlm.nih.gov/pubmed/33551869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fpsyt.2020.599588
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