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Metabolomic Description of Ivacaftor Elevating Polymyxin B Mediated Antibacterial Activity in Cystic Fibrosis Pseudomonas aeruginosa

[Image: see text] We have demonstrated that ivacaftor displays synergistic antibacterial activity in combination with polymyxin B against polymyxin-resistant Pseudomonas aeruginosa that commonly colonizes the lungs of people with cystic fibrosis (CF). However, the underlying mechanism(s) remain uncl...

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Bibliografische gegevens
Gepubliceerd in:ACS Pharmacol Transl Sci
Hoofdauteurs: Allobawi, Rafah, Ghelani, Drishti P., Schneider-Futschik, Elena K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2020
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296539/
https://ncbi.nlm.nih.gov/pubmed/32566909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00030
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