Dynamic Palmitoylation of the Sodium-Calcium Exchanger Modulates Its Structure, Affinity for Lipid-Ordered Domains, and Inhibition by XIP

The transmembrane sodium-calcium (Na-Ca) exchanger 1 (NCX1) regulates cytoplasmic Ca levels by facilitating electrogenic exchange of Ca for Na. Palmitoylation, the only reversible post-translational modification known to modulate NCX1 activity, controls NCX1 inactivation. Here, we show that palmitoy...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Gök, Caglar, Plain, Fiona, Robertson, Alan D., Howie, Jacqueline, Baillie, George S., Fraser, Niall J., Fuller, William
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296346/
https://ncbi.nlm.nih.gov/pubmed/32521252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107697
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