DHX33 Recruits Gadd45a To Cause DNA Demethylation and Regulates a Subset of Gene Transcription

RNA helicase DHX33 was found to regulate the transcription of multiple genes involved in cancer development. But the underlying molecular mechanism remains unclear. Here, we found DHX33 associated extensively with gene promoters at CG-rich region. Its deficiency reduced the loading of active RNA pol...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Feng, Weimin, Chen, Shiyun, Wang, Jiuling, Wang, Xingshun, Chen, Huaiyong, Ning, Wen, Zhang, Yandong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296211/
https://ncbi.nlm.nih.gov/pubmed/32312884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00460-19
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