DHX33 Recruits Gadd45a To Cause DNA Demethylation and Regulates a Subset of Gene Transcription

RNA helicase DHX33 was found to regulate the transcription of multiple genes involved in cancer development. But the underlying molecular mechanism remains unclear. Here, we found DHX33 associated extensively with gene promoters at CG-rich region. Its deficiency reduced the loading of active RNA pol...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Feng, Weimin, Chen, Shiyun, Wang, Jiuling, Wang, Xingshun, Chen, Huaiyong, Ning, Wen, Zhang, Yandong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296211/
https://ncbi.nlm.nih.gov/pubmed/32312884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00460-19
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