Enhancement of Antigen Presentation by Deletion of Viral Immune Evasion Genes Prevents Lethal Cytomegalovirus Disease in Minor Histocompatibility Antigen-Mismatched Hematopoietic Cell Transplantation

Hematoablative treatment followed by hematopoietic cell transplantation (HCT) for reconstituting the co-ablated immune system is a therapeutic option to cure aggressive forms of hematopoietic malignancies. In cases of family donors or unrelated donors, immunogenetic mismatches in major histocompatib...

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Veröffentlicht in:Front Cell Infect Microbiol
Hauptverfasser: Gezinir, Emin, Podlech, Jürgen, Gergely, Kerstin M., Becker, Sara, Reddehase, Matthias J., Lemmermann, Niels A. W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Cellular and Infection Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296086/
https://ncbi.nlm.nih.gov/pubmed/32582572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.00279
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