Transcriptional repression of Myc underlies the tumour suppressor function of AGO1 in Drosophila

Here, we report novel tumour suppressor activity for the Drosophila Argonaute family RNA-binding protein AGO1, a component of the miRNA-dependent RNA-induced silencing complex (RISC). The mechanism for growth inhibition does not, however, involve canonical roles as part of the RISC; rather, AGO1 con...

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Bibliografiske detaljer
Udgivet i:Development
Main Authors: Zaytseva, Olga, Mitchell, Naomi C., Guo, Linna, Marshall, Owen J., Parsons, Linda M., Hannan, Ross D., Levens, David L., Quinn, Leonie M.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7295588/
https://ncbi.nlm.nih.gov/pubmed/32527935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.190231
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