A de novo approach to inferring within-host fitness effects during untreated HIV-1 infection

In the absence of effective antiviral therapy, HIV-1 evolves in response to the within-host environment, of which the immune system is an important aspect. During the earliest stages of infection, this process of evolution is very rapid, driven by a small number of CTL escape mutations. As the infec...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Illingworth, Christopher J. R., Raghwani, Jayna, Serwadda, David, Sewankambo, Nelson K., Robb, Merlin L., Eller, Michael A., Redd, Andrew R., Quinn, Thomas C., Lythgoe, Katrina A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7295245/
https://ncbi.nlm.nih.gov/pubmed/32492061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008171
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