Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests

Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is one of the most widespread medically important arboviruses, causing human infections that result in mortality rates of up to 60%. We describe the selection of a high-affinity small protein (Affimer-NP) that binds specifically to the nucleopr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Negl Trop Dis
Prif Awduron: Álvarez-Rodríguez, Beatriz, Tiede, Christian, Hoste, Alexis C. R., Surtees, Rebecca A., Trinh, Chi H., Slack, Gillian S., Chamberlain, John, Hewson, Roger, Fresco, Alba, Sastre, Patricia, Tomlinson, Darren C., Millner, Paul A., Edwards, Thomas A., Barr, John N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7295242/
https://ncbi.nlm.nih.gov/pubmed/32492018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0008364
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