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Type I IFN drives experimental SLE by distinct mechanisms in CD4 T cells and B cells

Myriad studies have linked type I interferon (IFN) to the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE). While increased levels of type I IFN are found in patients with SLE, and IFN blockade ameliorates disease in many mouse models of lupus, its precise roles in d...

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Detalhes bibliográficos
Publicado no:Immunohorizons
Main Authors: Klarquist, Jared, Cantrell, Rachel, Lehn, Maria A., Lampe, Kristin, Hennies, Cassandra M., Hoebe, Kasper, Janssen, Edith M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294741/
https://ncbi.nlm.nih.gov/pubmed/32161059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/immunohorizons.2000005
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