Loss of Gimap5 promotes pathogenic CD4(+) T cell development and allergic airway disease: Gimap5-deficiency predisposes CD4(+) T cells to T(h)17 polarization

BACKGROUND: The GTPase of immunity-associated protein 5 is essential for lymphocyte homeostasis and survival. Recently, human GIMAP5 SNPs have been linked with an increased risk for asthma, while the loss of Gimap5 in mice has been associated with severe CD4(+) T celldriven immune pathology. OBJECTI...

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Publicado no:J Allergy Clin Immunol
Main Authors: Patterson, Andrew R., Bolcas, Paige, Lampe, Kristin, Cantrell, Rachel, Ruff, Brandy, Lewkowich, Ian, Hogan, Simon P., Janssen, Edith M., Bleesing, Jack, Khurana Hershey, Gurjit K., Hoebe, Kasper
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327968/
https://ncbi.nlm.nih.gov/pubmed/30616774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2018.10.018
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