Synthesis and Evaluation of (11)C- and (18)F-Labeled SOAT1 Inhibitors as Macrophage Foam Cell Imaging Agents

[Image: see text] PD-132301, an inhibitor of sterol O-acyltransferase 1 (SOAT1; also known as acyl-coenzyme A:cholesterol acyltransferase-1, ACAT1), is under clinical investigation for numerous adrenal disorders. Radiolabeled SOAT1 inhibitors could support drug discovery and help diagnose SOAT1-rela...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Hill, James R., Shao, Xia, Wright, Jay S., Stauff, Jenelle, Sherman, Phillip S., Arteaga, Janna, Wong, Ka Kit, Viglianti, Benjamin L., Scott, Peter J. H., Brooks, Allen F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2020
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294710/
https://ncbi.nlm.nih.gov/pubmed/32551015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00127
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