Discovery of a Potent Anticancer Agent PVHD303 with in Vivo Activity

[Image: see text] As a part of our continuous structure–activity relationship (SAR) studies on 1-(quinazolin-4-yl)-1-(4-methoxyphenyl)ethan-1-ols, the synthesis of derivatives and their cytotoxicity against the human lung cancer cell line A549 were explored. This led to the discovery of 1-(2-(furan-...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Suzuki, Yumiko, Otake, Ayana, Ueno, Satoshi, Hayashi, Kensuke, Ishii, Hirosuke, Miyoshi, Nao, Kuroiwa, Kenta, Tachikawa, Masashi, Fujimaki, Yuki, Nishiyama, Kotaro, Manabe, Kei, Yamazaki, Ryuta, Asai, Akira
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2020
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294709/
https://ncbi.nlm.nih.gov/pubmed/32551013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00119
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