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Synthesis and Structure–Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents

[Image: see text] A quinazoline derivative PVHD121 (1a) was shown to have strong antiproliferative activity against various tumor-derived cell lines, including A549 (lung), NCI-H460 (lung), HCT116 (colon), MCF7 (breast), PC3 (prostate), and HeLa (cervical) cells with IC(50) values from 0.1 to 0.3 μM...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Kuroiwa, Kenta, Ishii, Hirosuke, Matsuno, Kenji, Asai, Akira, Suzuki, Yumiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360158/
https://ncbi.nlm.nih.gov/pubmed/25815147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5004684
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