Structure Optimization of Gatastatin for the Development of γ-Tubulin-Specific Inhibitor

[Image: see text] Gatastatin (O(7)-benzyl glaziovianin A) is a γ-tubulin-specific inhibitor that is used to investigate γ-tubulin function in cells. We have previously reported that the unsubstituted phenyl ring of the O(7)-benzyl group in gatastatin is important for γ-tubulin inhibition. To obtain...

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Foilsithe in:ACS Med Chem Lett
Main Authors: Shintani, Kana, Ebisu, Haruna, Mukaiyama, Minagi, Hatanaka, Taisei, Chinen, Takumi, Takao, Daisuke, Nagumo, Yoko, Sakakura, Akira, Hayakawa, Ichiro, Usui, Takeo
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2020
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294552/
https://ncbi.nlm.nih.gov/pubmed/32550991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00526
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