Semisynthesis of an evasin from tick saliva reveals a critical role of tyrosine sulfation for chemokine binding and inhibition

Blood-feeding arthropods produce antiinflammatory salivary proteins called evasins that function through inhibition of chemokine-receptor signaling in the host. Herein, we show that the evasin ACA-01 from the Amblyomma cajennense tick can be posttranslationally sulfated at two tyrosine residues, alb...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Franck, Charlotte, Foster, Simon R., Johansen-Leete, Jason, Chowdhury, Sayeeda, Cielesh, Michelle, Bhusal, Ram Prasad, Mackay, Joel P., Larance, Mark, Stone, Martin J., Payne, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293604/
https://ncbi.nlm.nih.gov/pubmed/32461364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2000605117
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