Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

The interplay between E2 and E3 enzymes regulates the polyubiquitination of substrates in eukaryotes. Among the several RING-domain E3 ligases in humans, many utilize two distinct E2s for polyubiquitination. For example, the cell cycle regulatory E3, human Anaphase-Promoting Complex/Cyclosome (APC/C...

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Publicado no:Nat Struct Mol Biol
Main Authors: Martinez-Chacin, Raquel C., Bodrug, Tatyana, Bolhuis, Derek L., Kedziora, Katarzyna M., Bonacci, Thomas, Ordureau, Alban, Gibbs, Morgan E., Weissmann, Florian, Qiao, Renping, Grant, Gavin D., Cook, Jeanette G., Peters, Jan-Michael, Harper, J. Wade, Emanuele, Michael J., Brown, Nicholas G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293561/
https://ncbi.nlm.nih.gov/pubmed/32393902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0424-6
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