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Genetic screen for cell fitness in high or low oxygen highlights mitochondrial and lipid metabolism
Human cells are able to sense and adapt to variations in oxygen levels. Historically, much research in this field has focused on hypoxia inducible factor (HIF) signaling and reactive oxygen species (ROS). Here, we perform genome-wide CRISPR growth screens at 21%, 5%, and 1% oxygen to systematically...
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| Publicado no: | Cell |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7293541/ https://ncbi.nlm.nih.gov/pubmed/32259488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.03.029 |
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