Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance

Proper storage of excessive dietary fat into subcutaneous adipose tissue (SAT) prevents ectopic lipid deposition-induced insulin resistance, yet the underlying mechanism remains unclear. Here, we identify angiopoietin-2 (Angpt2)–integrin α5β1 signaling as an inducer of fat uptake specifically in SAT...

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Udgivet i:Nat Commun
Main Authors: Bae, Hosung, Hong, Ki Yong, Lee, Choong-kun, Jang, Cholsoon, Lee, Seung-Jun, Choe, Kibaek, Offermanns, Stefan, He, Yulong, Lee, Hyuek Jong, Koh, Gou Young
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293240/
https://ncbi.nlm.nih.gov/pubmed/32532986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16795-4
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