Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels

Melanoma represents the most serious type of skin cancer. Although recent years have seen advances using targeted and immunotherapies, most patients remain at high risk for tumor recurrence. Here we show that IRAK-M, a negative regulator of MyD88 signaling, is deficient or low in melanoma and expres...

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Udgivet i:Commun Biol
Main Authors: Geng, Degui, Ciavattone, Nicholas, Lasola, Jackline Joy, Shrestha, Rojesh, Sanchez, Amelia, Guo, Jitao, Vlk, Alexandra, Younis, Rania, Wang, Lucy, Brown, Alex J., Zhang, Yuji, Velasco-Gonzalez, Cruz, Tan, Aik-Choon, Davila, Eduardo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293221/
https://ncbi.nlm.nih.gov/pubmed/32533049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-1033-y
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