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TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes

The accumulation of protein aggregates is involved in the onset of many neurodegenerative diseases. Aggrephagy is a selective type of autophagy that counteracts neurodegeneration by degrading such aggregates. In this study, we found that LC3C cooperates with lysosomal TECPR1 to promote the degradati...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wetzel, Lisa, Blanchard, Stéphane, Rama, Sowmya, Beier, Viola, Kaufmann, Anna, Wollert, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293217/
https://ncbi.nlm.nih.gov/pubmed/32532970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16689-5
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