Light-Regulation of Enzyme Allostery through Photo-Responsive Unnatural Amino Acids

Imidazole glycerol phosphate synthase (ImGPS) is an allosteric bi-enzyme complex in which substrate binding to the synthase subunit HisF stimulates the glutaminase subunit HisH. To control this stimulation with light, we have incorporated the photo-responsive unnatural amino acids phenylalanine-4′-a...

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Vydáno v:Cell Chem Biol
Hlavní autoři: Kneuttinger, Andrea C., Straub, Kristina, Bittner, Philipp, Simeth, Nadja A., Bruckmann, Astrid, Busch, Florian, Rajendran, Chitra, Hupfeld, Enrico, Wysocki, Vicki H., Horinek, Dominik, König, Burkhard, Merkl, Rainer, Sterner, Reinhard
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293202/
https://ncbi.nlm.nih.gov/pubmed/31495713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.08.006
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