Human biodistribution and internal dosimetry of 4-[ (18)F]fluorobenzyl-dexetimide: a PET radiopharmaceutical for imaging muscarinic acetylcholine receptors in the brain and heart

BACKGROUND: 4-[(18)F] fluorobenzyl dexetimide (F-DEX) is the first non-subtype selective fluorine-18 labelled tracer for muscarinic receptors (mAChR) used in humans. A recent first-in-human study found high regional brain uptake with low variation in normal subjects. Disturbance of mAChR has been re...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: Pain, Cameron D., O’Keefe, Graeme J., Ackermann, Uwe, Dore, Vincent, Villemagne, Victor L., Rowe, Christopher C.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7292855/
https://ncbi.nlm.nih.gov/pubmed/32533449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-020-00641-1
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