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Unbound Plasma, Total Plasma, and Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation

ABSTRACT: Therapeutic drug monitoring of tacrolimus whole-blood concentrations is standard care in thoracic organ transplantation. Nevertheless, toxicity may appear with alleged therapeutic concentrations possibly related to variability in unbound concentrations. However, pharmacokinetic data on unb...

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Detalhes bibliográficos
Publicado no:Clin Pharmacokinet
Main Authors: Sikma, Maaike A., Van Maarseveen, Erik M., Hunault, Claudine C., Moreno, Javier M., Van de Graaf, Ed A., Kirkels, Johannes H., Verhaar, Marianne C., Grutters, Jan C., Kesecioglu, Jozef, De Lange, Dylan W., Huitema, Alwin D. R.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7292814/
https://ncbi.nlm.nih.gov/pubmed/31840222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-019-00854-1
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