Early manifestation of depressive‐like behavior in transgenic mice that express dementia with Lewy body‐linked mutant β‐synuclein

AIM: We previously generated transgenic (Tg) mice that expressed P123H β‐synuclein (βS), a dementia with Lewy body‐linked mutant βS. Notably, these mice recapitulated neurodegenerative features of Lewy body disease, reflected by motor dysfunction, greater protein aggregation, and memory impairment....

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Gepubliceerd in:Neuropsychopharmacol Rep
Hoofdauteurs: Fujita, Masayo, Hagino, Yoko, Takamatsu, Yukio, Shimizu, Yuka, Takamatsu, Yoshiki, Ikeda, Kazutaka, Hashimoto, Makoto
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
Onderwerpen:
Micro Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7292266/
https://ncbi.nlm.nih.gov/pubmed/30106256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/npr2.12009
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