Novel Multiplex Droplet Digital PCR Assays to Monitor Minimal Residual Disease in Chronic Myeloid Leukemia Patients Showing Atypical BCR-ABL1 Transcripts

BCR-ABL1 fusion transcript is the minimal residual disease marker in chronic myeloid leukemia; 2% of patients show unusual breakpoints generating atypical transcripts, not quantifiable by standardized real-time PCR (RT–PCR). Response monitoring is performed by non-quantitative NESTED PCR, useless fo...

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Udgivet i:J Clin Med
Main Authors: Petiti, Jessica, Lo Iacono, Marco, Dragani, Matteo, Pironi, Lucrezia, Fantino, Cristina, Rapanotti, Maria Cristina, Quarantelli, Fabrizio, Izzo, Barbara, Divona, Mariadomenica, Rege-Cambrin, Giovanna, Saglio, Giuseppe, Gottardi, Enrico Marco, Cilloni, Daniela, Fava, Carmen
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7290999/
https://ncbi.nlm.nih.gov/pubmed/32414125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm9051457
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