Detection of BCR-ABL T315I mutation by peptide nucleic acid directed PCR clamping and by peptide nucleic acid FISH

BACKGROUND: Mutations of the BCR-ABL1 fusion gene represent a well established cause of resistance to tyrosine kinase inhibitors. Among the different mutations identified T315I is of particular concern since it is not effectively targeted by the majority of Tyrosine Kinase Inhibitors so far availabl...

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發表在:Biomark Res
Main Authors: Rosso, Valentina, Bracco, Enrico, Pedrola, Roberto, Carturan, Sonia, Signorino, Elisabetta, Petiti, Jessica, Calabrese, Chiara, Nicoli, Paolo, De Gobbi, Marco, Gaidano, Valentina, Gallo, Daniela, Ulisciani, Stefano, Fava, Carmen, Rege-Cambrin, Giovanna, Frassoni, Francesco, Saglio, Giuseppe, Cilloni, Daniela
格式: Artigo
語言:Inglês
出版: BioMed Central 2015
主題:
Methodology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490729/
https://ncbi.nlm.nih.gov/pubmed/26146560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40364-015-0039-y
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