Detection of BCR-ABL T315I mutation by peptide nucleic acid directed PCR clamping and by peptide nucleic acid FISH

BACKGROUND: Mutations of the BCR-ABL1 fusion gene represent a well established cause of resistance to tyrosine kinase inhibitors. Among the different mutations identified T315I is of particular concern since it is not effectively targeted by the majority of Tyrosine Kinase Inhibitors so far availabl...

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Enregistré dans:
Détails bibliographiques
Publié dans:Biomark Res
Auteurs principaux: Rosso, Valentina, Bracco, Enrico, Pedrola, Roberto, Carturan, Sonia, Signorino, Elisabetta, Petiti, Jessica, Calabrese, Chiara, Nicoli, Paolo, De Gobbi, Marco, Gaidano, Valentina, Gallo, Daniela, Ulisciani, Stefano, Fava, Carmen, Rege-Cambrin, Giovanna, Frassoni, Francesco, Saglio, Giuseppe, Cilloni, Daniela
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Methodology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490729/
https://ncbi.nlm.nih.gov/pubmed/26146560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40364-015-0039-y
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