Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms

A major risk factor for major depressive disorder (MDD) is stress. Stress leads to the release of high-mobility group box-1 (HMGB1), which in turn leads to neuroinflammation, a potential pathophysiological basis of MDD. The mechanism underlying stress-induced HMGB1 release is not known, but stress-a...

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Pubblicato in:Cells
Autori principali: Hisaoka-Nakashima, Kazue, Azuma, Honami, Ishikawa, Fumina, Nakamura, Yoki, Wang, Dengli, Liu, Keyue, Wake, Hidenori, Nishibori, Masahiro, Nakata, Yoshihiro, Morioka, Norimitsu
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7290518/
https://ncbi.nlm.nih.gov/pubmed/32344830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9051068
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