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Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism

The high incidence of aneuploidy in the embryo is considered the principal cause for low human fecundity. However, the prevalence of aneuploidy dramatically declines as pregnancy progresses, with the steepest drop occurring as the embryo completes implantation. Despite the fact that the plasticity o...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Singla, Shruti, Iwamoto-Stohl, Lisa K., Zhu, Meng, Zernicka-Goetz, Magdalena
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7290028/
https://ncbi.nlm.nih.gov/pubmed/32528010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16796-3
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