The KDM Inhibitor GSKJ4 Triggers CREB Downregulation via a Protein Kinase A and Proteasome-Dependent Mechanism in Human Acute Myeloid Leukemia Cells

Acute myeloid leukemia (AML) is a progressive hematopoietic-derived cancer arising from stepwise genetic mutations of the myeloid lineage. cAMP response element-binding protein (CREB) is a nuclear transcription factor, which plays a key role in the multistep process of leukemogenesis, thus emerging...

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Publicado en:Front Oncol
Autores principales: Illiano, Michela, Conte, Mariarosaria, Salzillo, Alessia, Ragone, Angela, Spina, Annamaria, Nebbioso, Angela, Altucci, Lucia, Sapio, Luigi, Naviglio, Silvio
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289982/
https://ncbi.nlm.nih.gov/pubmed/32582541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00799
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