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Berberine Mediated Positive Inotropic Effects on Rat Hearts via a Ca(2+)-Dependent Mechanism

Previous studies showed that berberine, an alkaloid from Coptis Chinensis Franch, might exert a positive inotropic effect on the heart. However, the underlying mechanisms were unclear. Here, we reported that berberine at 10–20 µM increased the left ventricular (LV) developed pressure and the maximal...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Zhao, Junli, Wang, Yaqian, Gao, Jie, Jing, Yang, Xin, Wenkuan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289965/
https://ncbi.nlm.nih.gov/pubmed/32581792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00821
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