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Assessing parameter uncertainty in small-n pharmacometric analyses: value of the log-likelihood profiling-based sampling importance resampling (LLP-SIR) technique

Assessing parameter uncertainty is a crucial step in pharmacometric workflows. Small datasets with ten or fewer subjects appear regularly in drug development and therapeutic use, but it is unclear which method to assess parameter uncertainty is preferable in such situations. The aim of this study wa...

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Bibliografiske detaljer
Udgivet i:J Pharmacokinet Pharmacodyn
Main Authors: Broeker, Astrid, Wicha, Sebastian G.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289778/
https://ncbi.nlm.nih.gov/pubmed/32248328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-020-09682-4
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