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Mitochondrial DNA in innate immune responses and inflammatory pathology

Mitochondrial DNA (mtDNA) — which is well known for its role in oxidative phosphorylation and maternally inherited mitochondrial diseases — is increasingly recognized as an agonist of the innate immune system that influences antimicrobial responses and inflammatory pathology. On entering the cytopla...

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Detalhes bibliográficos
Publicado no:Nat Rev Immunol
Main Authors: West, A. Phillip, Shadel, Gerald S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289178/
https://ncbi.nlm.nih.gov/pubmed/28393922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nri.2017.21
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