Dexmedetomidine inhibits LPS-induced proinflammatory responses via suppressing HIF1α-dependent glycolysis in macrophages

Dexmedetomidine, a highly selective α2-adrenoceptor agonist, has been reported to exert an anti-inflammatory effect in several animal models, but the mechanism remains unclear. Previous studies have shown that hypoxia inducible factor 1α-induced glycolysis is essential for the activation of inflamma...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Aging (Albany NY)
Asıl Yazarlar: Meng, Qingyuan, Guo, Pinhao, Jiang, Zhengyu, Bo, Lulong, Bian, Jinjun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals 2020
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7288940/
https://ncbi.nlm.nih.gov/pubmed/32433037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103226
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