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Anticancer Ruthenium Complexes with HDAC Isoform Selectivity

The histone deacetylase (HDAC) enzymes have emerged as an important class of molecular targets in cancer therapy, with five inhibitors in clinical use. Recently, it has been shown that a lack of selectivity between the 11 Zn-dependent HDAC isoforms may lead to unwanted side-effects. In this paper, w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Molecules
Hauptverfasser: Cross, Jasmine M., Blower, Tim R., Kingdon, Alexander D. H., Pal, Robert, Picton, David M., Walton, James W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7287671/
https://ncbi.nlm.nih.gov/pubmed/32455529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25102383
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