Nitro-oleic acid, a ligand of CD36, reduces cholesterol accumulation by modulating oxidized-LDL uptake and cholesterol efflux in RAW264.7 macrophages

Macrophages play a pivotal role in the early stages of atherosclerosis development; they excessively accumulate cholesterol in the cytosol in response to modified Low Density Lipoprotein (mLDL). The mLDL are incorporated through scavenger receptors. CD36 is a high-affinity cell surface scavenger rec...

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Détails bibliographiques
Publié dans:Redox Biol
Auteurs principaux: Vazquez, Matias M., Gutierrez, Maria V., Salvatore, Sonia R., Puiatti, Marcelo, Dato, Virginia Actis, Chiabrando, Gustavo A., Freeman, Bruce A., Schopfer, Francisco J., Bonacci, Gustavo
Format: Artigo
Langue:Inglês
Publié: Elsevier 2020
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7287307/
https://ncbi.nlm.nih.gov/pubmed/32531545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101591
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