DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver

Aging is associated with reduced liver function that may increase the risk for adverse drug reactions in older adults. We hypothesized that age-related changes to epigenetic regulation of genes involved in drug metabolism may contribute to this effect. We reviewed published epigenome-wide studies of...

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Veröffentlicht in:GeroScience
Hauptverfasser: Kronfol, Mohamad M., Jahr, Fay M., Dozmorov, Mikhail G., Phansalkar, Palak S., Xie, Lin Y., Aberg, Karolina A., McRae, MaryPeace, Price, Elvin T., Slattum, Patricia W., Gerk, Philip M., McClay, Joseph L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7287002/
https://ncbi.nlm.nih.gov/pubmed/32221779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00181-5
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