DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver

Aging is associated with reduced liver function that may increase the risk for adverse drug reactions in older adults. We hypothesized that age-related changes to epigenetic regulation of genes involved in drug metabolism may contribute to this effect. We reviewed published epigenome-wide studies of...

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Detalhes bibliográficos
Publicado no:GeroScience
Main Authors: Kronfol, Mohamad M., Jahr, Fay M., Dozmorov, Mikhail G., Phansalkar, Palak S., Xie, Lin Y., Aberg, Karolina A., McRae, MaryPeace, Price, Elvin T., Slattum, Patricia W., Gerk, Philip M., McClay, Joseph L.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7287002/
https://ncbi.nlm.nih.gov/pubmed/32221779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00181-5
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