Neurofibromin is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer

We report that neurofibromin, a tumor suppressor and Ras-GAP (GTPase Activating Protein), is also an estrogen receptor-α (ER) transcriptional co-repressor through leucine/isoleucine-rich motifs that are functionally independent of GAP activity. GAP activity, in turn, does not impact ER binding. Cons...

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Publicado en:Cancer Cell
Autores principales: Zheng, Ze-Yi, Anurag, Meenakshi, Lei, Jonathan T., Cao, Jin, Singh, Purba, Peng, Jianheng, Kennedy, Hilda, Nguyen, Nhu-Chau, Chen, Yue, Lavere, Philip, Li, Jing, Du, Xin-Hui, Cakar, Burcu, Song, Wei, Kim, Beom-Jun, Shi, Jiejun, Seker, Sinem, Chan, Doug W., Zhao, Guo-Qiang, Chen, Xi, Banks, Kimberly C., Lanman, Richard B., Shafaee, Maryam Nemati, Zhang, Xiang H.-F., Vasaikar, Suhas, Zhang, Bing, Hilsenbeck, Susan G., Li, Wei, Foulds, Charles E., Ellis, Matthew J., Chang, Eric C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286719/
https://ncbi.nlm.nih.gov/pubmed/32142667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.02.003
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