Restoring functional neurofibromin by protein transduction

In Neurofibromatosis 1 (NF1) germ line loss of function mutations result in reduction of cellular neurofibromin content (NF1+/−, NF1 haploinsufficiency). The Ras-GAP neurofibromin is a very large cytoplasmic protein (2818 AA, 319 kDa) involved in the RAS-MAPK pathway. Aside from regulation of prolif...

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Udgivet i:Sci Rep
Main Authors: Mellert, K., Lechner, S., Lüdeke, M., Lamla, M., Möller, P., Kemkemer, R., Scheffzek, K., Kaufmann, D.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906691/
https://ncbi.nlm.nih.gov/pubmed/29670214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24310-5
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