Macrophages Potentiate STAT3 Signaling in Skeletal Muscles and Regulate Pancreatic Cancer Cachexia

Incidence of cachexia is highly prevalent in pancreatic ductal adenocarcinoma (PDAC); advanced disease stage directly correlates with decreased muscle and fat mass in PDAC patients. The pancreatic tumor microenvironment is central to the release of systemic factors that govern lipolysis, proteolysis...

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Udgivet i:Cancer Lett
Main Authors: Shukla, Surendra K., Markov, Spas D., Attri, Kuldeep S., Vernucci, Enza, King, Ryan J., Dasgupta, Aneesha, Grandgenett, Paul M., Hollingsworth, Michael A., Singh, Pankaj K., Yu, Fang, Mehla, Kamiya
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286478/
https://ncbi.nlm.nih.gov/pubmed/32344015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.04.017
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