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Evolution of Substrates and Components of the Pro/N-Degron Pathway

Gid4, a subunit of the ubiquitin ligase GID, is the recognition component of the Pro/N-degron pathway. Gid4 targets proteins in particular through their N-terminal (Nt) proline (Pro) residue. In Saccharomyces cerevisiae and other Saccharomyces yeasts, the gluconeogenic enzymes Fbp1, Icl1, and Mdh2 b...

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Publicat a:Biochemistry
Autors principals: Chen, Shun-Jia, Melnykov, Artem, Varshavsky, Alexander
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286083/
https://ncbi.nlm.nih.gov/pubmed/31895557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00953
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